Figure 3 - full size

 

Figure 3.
Figure 3 Structure of the BC, DE and FG loops of 4. (a) Close-up view of the BC (yellow) and DE (pink) loops; the side chain of R1014 plays a central role in the stabilization of this region by establishing hydrogen bonds within the BC loop and with the backbone of the DE loop. D990 in the N-terminus (grey) makes a hydrogen bond to the backbone of the BC loop. (b) Detailed view of the -hairpin at the FG loop. The relative position of the residues that form the type I' -turn (1087-1090) is shown in parentheses. Hydrogen bonds are shown as dashed lines.

The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (2009, 65, 858-871) copyright 2009.