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Figure 3.
Fig. 3. Tether repeat (TR) motif. (a) Structural features of
the 12 TRs in the p115^Nt monomer. Except for the C-terminal TR,
each TR includes three α-helices, which are shown in salmon,
yellow and light blue, respectively. The insertions between any
adjacent helices are colored gray. Arg39 is shown in
ball-and-stick representation; the side view is in the left-hand
panel, and the top view is in the right-hand panel. (b) The
conformation of three adjacent tether repeats (TR5, TR6, and
TR7) highlights the tight packing of the conserved hydrophobic
core throughout the solenoid, where the hydrophobic residues
involved in stabilizing the solenoid are shown in ball-and-stick
representation. (c) Superimposition of the three 12 TR motifs
from the dimer and monomer p115^Nt structures show the
structural conservation.
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