|
Figure 3.
MSVIII-19 induces full domain closure in the ligand-binding
core of iGluR5. A, superimposition of the MSVIII-19 (cyan), DH
(yellow), and l-glutamate (Protein Data Bank code 1YCJ, molecule
A; salmon) complexes with iGluR5-S1S2 on D1 residues. B,
superimposition of the MSVIII-19 (cyan) and UBP302 (Protein Data
Bank code 2F35, molecule A; blue) complexes with iGluR5-S1S2 on
D1 residues. The high degree of domain closure introduced by
MSVIII-19 compared with UBP302 is evident from the change of the
D2 domain position.
|
