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Figure 3.
Figure 3. Molecular Interface between DDX6-C and EDC3-FDF
DDX6-C (gray) and EDC3-FDF (salmon) are shown as ribbons
with selected side-chain and main-chain atoms as sticks (oxygens
in red, nitrogens in blue, sulfurs in yellow). Fixed water
molecules are shown as red spheres and hydrogen bonds and salt
bridges as dotted lines.
(A) Interactions of the N-terminal
loop, the FDF motif, and α helix H1. The four residues mutated
in DDX6-C^Mut-1 have boxed labels.
(B) Interactions of the
N-terminal loop, the FDF motif, and α helix H1. β strand β8
is drawn as a loop for clarity.
(C) Interactions of the FDK
motif and α helix H2. Equivalent residues mutated in
Me31B^Mut-2 have boxed labels.
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