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Figure 3.
Hydrophobic plug-socket interaction of the Polη (A) or Polι
(B) peptide with PCNA and superimposition of PIP-box structures
bound to PCNA (C). A and B, PCNA is shown by a surface model,
and residues of PCNA that interact with the three-forked
hydrophobic plug are colored gray. PIP-box residues are shown by
stick models. Residues of PCNA that interact with the Met-701
(p1) residue of Polη in the Q-pocket are colored light pink. C,
structures of p21, Polη, Polκ, and Polι bound to PCNA are
shown in light blue, pink, green, and yellow, respectively.
PIP-box residues are shown by stick models, and only some
PIP-box residues of Polι are denoted.
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