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Figure 3.
C2-Cer bound in the putative active site of PaCD and a
proposed reactionmechanism.A, the structural comparison between
substrate-unbound and C2 Cer-bound forms of PaCD. The
substrate-unbound form is shown in red, whereas the C2 Cer-bound
form is shown in green. B, the binding model of C2-Cer is shown
as a stick representation with oxygen atoms in red, nitrogen
atoms in blue, and carbon atoms in yellow. The electron density
map was calculated at the 1.0 σ level. C, schematic drawing of
the binding model of C2-Cer. The hydrogen bonds and the metal
coordinate ion structure was shown by dotted lines. D, a
proposed reaction mechanism of PaCD based on the structural data.
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