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Figure 3.
Mode of inhibitors binding to Lyn PTK. A, interaction between
AMP-PNP and Lyn PTK. B, interaction between PP2 and Lyn PTK. C,
interaction between Dasatinib and Lyn PTK. Left panel, the side
chains of residues that interact with the inhibitor are shown,
as are main-chain atoms and water molecules participating in
hydrogen bonds. Right panel, corresponding view of the inhibitor
in a ball-and-stick representation and covered with the
simulated annealing omit-map Fo-Fc electron density map
contoured at 2σ.
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