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Figure 3.
Fig. 3. Detailed view of the cap binding site of the PARN-RRM
with bound m^7GTP. The m^7GTP cap (shown in ball-and-stick mode)
binds on the surface of the N-terminal part of the RRM domain
involving the loops connecting β2 and β3 strands as well as
the β1 strand and the α1 helix. The 2|F[o]| − |F[c]|
electron density (blue) corresponding to the bound m^7GTP is
contoured at 1.1 σ. The interacting residues are depicted in
ball-and-stick mode. The guanine moiety stacks on the side chain
of Trp475 and is bound by several hydrogen bonds. A water
molecule mediating hydrogen bonds between Thr458 and the
exocyclic oxygen O6 of the cap guanine is colored orange.
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