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Figure 3.
Fig. 3. Crystal structure of HSA complexed with fusidic
acid. (a) Simulated annealing F[o] – F[c] omit map contoured
at 1.75σ showing the drug bound to sub-domain IB of HSA.
Fusidic acid is shown in a stick representation with atoms
colored by atom-type: C, light blue; O, red; N blue. (b) Overall
structure of HSA complexed with fusidic acid. The drug, depicted
with space-filling spheres, binds to sub-domains IB and IIIB.
(c) Detailed view of the interactions of fusidic acid with the
binding pocket in sub-domain IB. Hydrogen bonds are
indicated by broken yellow lines. Selected protein sidechains
are shown as sticks (with carbon atoms colored grey). (d) View
of the fit of fusidic acid to the binding pocket in sub-domain
IB (pink, semi-transparent surface). (e) Same as in d but
rotated  vert,
similar 90° about a vertical axis.
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