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Figure 3.
Phosphate binding to Fe65-PTB1 suggests
phosphotyrosine-dependent peptide interactions. A, close-up view
of the Fe65-PTB1 Tyr(P) binding pocket. The hydrogen-bonding
network of the phosphate group is indicated by dashed lines. B,
superposition of phosphate-bound Fe65-PTB1 with the IRS-1 PTB
domain (PDB code 1irs). The bound NPApY motif of the bound
peptide to IRS-1 is shown together with the two respective IRS-1
arginine residues of the binding pocket (gray). C,
phosphate-bound Fe65-PTB1 superposed to the Dab1/APP
nonphosphorylated peptide, including the NPTY motif (PDB code
1oqn).
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