Figure 3 - full size

Figure 3. The structure of the Y72A mutant reveals cleaved AP DNA (a) and ordered water molecules (b) adjacent to the cleaved AP site (3 light blue and 4 dark blue contoured omit maps). Panels a and b are drawn in stereoview. (c) The structures of wild-type (left) and Y72A mutant (right) Endo IV bound to AP DNA product are virtually superimposable. Removal of the Tyr72 side chain allows increased solvation of the active site.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Mol Biol (2008, 15, 515-522) copyright 2008.