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Figure 3.
Stereo representations of the PCI–thrombin complex bridged
by a 14-mer heparin chain. (A) The ribbon diagram is rotated
150° relative to the view shown in Fig. 1A to illustrate the
alignment of the heparin-binding regions. A 14-mer heparin chain
(green rods) is placed onto the modeled disaccharide to yield a
bridged complex with fully occupied heparin-binding sites. (B)
The electrostatic surface of the complex in the same orientation
as in A reveals the continuous basic (blue) heparin-binding
sites of thrombin (Upper) and PCI (Lower).
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