|
Figure 3.
Figure 3. Crystal Structure of the DGKSAM Polymer
(A)
Space-filling model of the DGKSAM polymer showing the helical
structure. Every other subunit is colored green or yellow. Two
of the subunits are shown as ribbon diagrams.
(B) A ribbon
model showing a close-up view of the oligomeric interface. The
end-helix (EH, green) surface of one SAM domain contacts the
mid-loop (ML, yellow) surface of another SAM domain forming
head-to-tail interaction. Side-chains important in mediating
this interaction are shown and colored according to the surface
on which they reside. For sequence orientation: The V52, G53,
K56, E35G, and D43 in the DGKSAM structure correspond to V1148,
G1149, K1152, E1131, D1139, and C1116 in the full-length DGKδ1.
|
