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Figure 3.
X-ray crystal structure of thienopyrimidine 6 in ErbB-4. (A)
Overlay of the ErbB-4 complexed with 6 (green) and EGFR
complexed with lapatinib (yellow). (B) Overlay of the active
sites of ErbB-4 (green) and EGFR (yellow). The covalent bond
between ErbB-4 and 6 is shown as a dotted green line. The
location of a hydrogen bond between the pyrimidine N1 of 6 and
the hinge region of ErbB-4 is shown by a dashed line. (C) Omit
map density for the ErbB-4 inhibitor complex contoured at 1
sigma.
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