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Figure 3.
FIGURE 3. sIBB-(25-65) domain versus  IBB-(11-54) domain. a,
left panel, structure of importin β- IBB complex (in purple
and blue, respectively) superimposed to that of the importin
β-sIBB-(25-65) complex (in green and magenta, respectively) of
crystal form I. Right panel, blowup of the IBB and sIBB-(25-65)
domains (colored in blue and magenta, respectively) translated
out of the superimposition. Significant differences are observed
in the structure of the two peptides. b, schematic diagram of
the interactions between HEAT repeats 7-19 of importin β and
the sIBB-(25-65) domain (top) as compared with the IBB-(11-54) domain
(bottom). HEAT repeats are referred to as H7-19. Colored in red
in the primary sequence of the sIBB-(25-65) and IBB-(11-54) domain are
identical residues. Intermolecular polar and hydrophobic
interactions are shown as red and green lines, respectively.
Intramolecular contacts within IBB domains are indicated by red
brackets.
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