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Figure 3.
Figure 3. Pseudosubstrate Autoinhibition by the Sec7-PH
Linker and C-Terminal Helix
(A) Intramolecular interactions
at the interface between the linker and Sec7 domain.
(B)
Intramolecular interactions at the interface between the
C-terminal helix and Sec7 domain.
(C and D) Comparison of
the linker and C-terminal helix of Grp1 with the switch I and II
regions of Arf1-GDP from the complex with the E156K mutant of
the ARNO Sec7 domain (PDB ID code 1R8S) after superposition of
Cα atoms.
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