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Figure 3.
Fig. 3. The overall conformation of Impβ in complex with
IBB[SPN1] and IBB[α], respectively, differs significantly. (a)
Superposition of the structures of Impβ/IBB[SPN1] (blue) and
Impβ/IBB[α] (red). Only Impβ is shown in each case. The
superposition reveals a considerable difference of 14 Å in
the dilatation of both molecules. The distances between Asn141
and Ala876 were measured and are indicated. (b) Comparison
between a homology amino acid sequence alignment^17 and a
structure-based sequence alignment of IBB[α] and IBB[SPN1]
derived from the crystal structures of Impβ/IBB[α] and
Impβ/IBB[SPN1]: Green boxes indicate functionally conserved
residues regarding interaction with Impβ; red boxes mark
residues of IBB[α] that interact with the acidic loop of Impβ.
They also mark the corresponding amino acids of IBB[SPN1]
according to Ref. 9.
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