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Figure 3.
Figure 3 Overall domain architecture of neuropilins. (A) Domain
organization of Nrp2 (blue, a1; green, a2; yellow, b1; red, b2)
in complex with the Fab fragment of anti-panNrp^A (tan, heavy
chain; gray, light chain). N-glycosylated residues are indicated
in magenta. (B) Ribbon representation of the Nrp a2b1b2
structures; the orange spheres highlight a bound calcium ion.
(C) Superposition of the Nrp2/Fab complex from two different
crystal forms based on the a2b1b2 domains. Note the poor
superposition of the a1 domains (yellow arrows) in comparison to
the a2b1b2 region (black arrows). Structure figures were
produced with PyMol (http://www.pymol.org).
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