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Figure 3.
Figure 3. EBD Binds to a Well-Defined Groove at the Bottom of
EED
(A) A schematic representation of EED and the
EED-binding domain in EZH2 (EBD) (residues 39–68). EED and EBD
are shown in cyan and orange, respectively.
(B)
Electrostatic complementarity between EED and EBD. Both EED and
EBD are represented in electrostatic surface. The positive,
negative, and neutral surfaces are colored in blue, red, and
white, respectively. To distinguish between EED and EBD, EBD is
also shown as a cartoon (cyan).
(C) Shape complementarity
between EED and EBD. EED and EBD are represented in mesh and
surface, respectively.
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