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Figure 3.
Figure 3. A Two-State Model for INAD PDZ5
A detailed
view of the binding pocket in oxidized and reduced states of
INAD PDZ5 (A) and in the C645S mutant structure (B). Key
specificity-determining residues (F642 and F649) on the α2
helix adopt significantly different conformations in the
oxidized and reduced states; the C645S mutant is effectively
locked in the reduced state structure.
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