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Figure 3.
Fig. 3. (a) Secondary structure arrangement of the catalytic
metalloprotease domain (red and yellow) and of the cysteine-rich
domain (green) of ADAMTS-1 in complex with bound marimastat. The
catalytic zinc ion (purple) and two presumed cadmium ions bound
to the calcium-binding site (peach) are shown as spheres, while
the complexed marimastat ligand is shown as a ball-and-stick
model. Disulphide bonds are indicated. This and all other
molecular illustrations here were prepared using PyMol
[http://www.pymol.org]. (b) Structural superposition of human
ADAMTS-1 (red) and human ADAM33 (green) indicating the conserved
structure of the catalytic domain.
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