Figure 3.
Fig. 3. Electrostatics of binding. The electrostatic
potential surface of PFA1 with bound peptide. Blue represents
positive charge, red indicates negative charge, and the apolar
surface is shown in white. The A (1–8) peptide is drawn
with carbon (yellow), nitrogen (blue), and oxygen (red).
Although the Arg 5 residue sits in a pocket of strong negative
charge, the Glu 3 residue has no correspondingly positive region
around it. This position is susceptible to substitution and
cross-reaction.
(1–8) peptide is drawn
with carbon (yellow), nitrogen (blue), and oxygen (red).
Although the Arg 5 residue sits in a pocket of strong negative
charge, the Glu 3 residue has no correspondingly positive region
around it. This position is susceptible to substitution and
cross-reaction.