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Figure 3.
Structure of the UBA domain from c-Cbl.A, ribbon
representation of the UBA dimer. One protomer is shown in
magenta, another is in yellow. Helices are labeled as α1-α3 in
one protomer and α1′-α3′ in another protomer. B,
hydrophobic core of the c-Cbl UBA domain. Respective residues
are shown as sticks and labeled. C, the enlarged view of the
hydrophobic dimer interface. Key residues in the dimer are shown
as sticks and labeled. D, intermolecular hydrogen bonds (dotted
line) involving Lys^876 and Glu^894 from both c-Cbl UBA
protomers.
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