Figure 3.
(a) Active site of JMJD2A bound to KG
(green carbons) and H3K9me3 (yellow carbons). Orange and green
dashed lines represent conventional and CH O
hydrogen bonds; blue dashed lines represent bonds coordinating
Ni(II). Side chain or main chain atoms of certain residues are
omitted for clarity. (b) Trimethyl -ammonium
cation of H3K9me3 and methylammonium-binding pocket residue
interactions. CH O
hydrogen bonds are shown in green and labeled with distances.
Inset, electron density of the simulated annealing omit map
(contoured at 2.0 )
corresponding to the trimethylated -ammonium
cation. (c,d) JMJD2A active site in complex with H3K36me3 (cyan
carbons) and NOG (c) and with H3K36me2 (orange carbons) and
succinate (d). Hydrogen bonds are depicted as in a.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2007,
14,
689-695)
copyright 2007.
KG
(green carbons) and H3K9me3 (yellow carbons). Orange and green
dashed lines represent conventional and CH 
-ammonium
cation of H3K9me3 and methylammonium-binding pocket residue
interactions. CH 
)
corresponding to the trimethylated