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Figure 3.
Figure 3. Comparison with the nucleotide-free Sec7–Arf GTPase
complex. (a) Nucleotide-free RAB21 in complex with the
HB-VPS9 tandem of RABEX-5. (b) Nucleotide-free ARF1 in complex
with the Sec7 domain of Gea2 (ref. 39). The helices that
comprise the core of the GTPase-binding sites in the VPS9 and
Sec7 domains are depicted in brown. The invariant P-loop lysine
(RAB21 and ARF1), aspartic acid finger (VPS9 domain) and
glutamic acid finger (Sec7 domain) are depicted as spheres.
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