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Figure 4.
Figure 4. Cavities on IREM-1. The cavities on IREM-1 are
shown as yellow dots and are labelled from 1 to 4. The locations
of the CDReq loops are shown schematically and are labelled only
in the ribbon diagram. In (b) and (d) the continuous groove
formed by cavities 1, 2 and 3 is highlighted. This groove, which
possesses a negative potential and is highly hydrophobic, may
accommodate potential ligands. The electrostatic potential
surfaces and hydrophobicity are coloured as in Figure 3. The
ribbon orientation is equivalent to that of Figure 1(a).
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