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Figure 3.
Figure 3. (a) Overall comparison of the vWFA domain of C2a
(magenta) and isolated vWFA domain of Bb (yellow). The magnesium
ion of C2a is shown in silver and that of Bb is shown in pink.
The N-terminal linker of C2a is shown in red and the disordered
α7 helix of Bb is shown by a yellow dotted line. (b) Stereo
view comparison of the α7 helix and its environment of C2a with
other known integrin I-domain “open” and “closed”
structures. C2 is in magenta; the ligand-free α2β1 I-domain
closed form is in yellow, the ligand-bound α2β1 I-domain is in
cyan and the Bb^C428–C435 mutant of Bb is in green. (c)
Stereo view of superposition of the α7 helix and its
environment of C2a (magenta) and Bb (yellow). The linker to the
SP domain of C2a shown in blue and that to Bb is shown in
green. The additional N terminus of C2a is shown in red. The
sugar molecule of C2a that is located at the domain interface
near the α7 helix is shown in white and labeled as NAG. The
magnesium ion of C2a is shown in silver and that of Bb is shown
in yellow. Figure 3. (a) Overall comparison of the vWFA
domain of C2a (magenta) and isolated vWFA domain of Bb (yellow).
The magnesium ion of C2a is shown in silver and that of Bb is
shown in pink. The N-terminal linker of C2a is shown in red and
the disordered α7 helix of Bb is shown by a yellow dotted line.
(b) Stereo view comparison of the α7 helix and its environment
of C2a with other known integrin I-domain “open” and
“closed” structures. C2 is in magenta; the ligand-free
α2β1 I-domain closed form is in yellow, the ligand-bound
α2β1 I-domain is in cyan and the Bb^C428–C435 mutant of Bb
is in green. (c) Stereo view of superposition of the α7 helix
and its environment of C2a (magenta) and Bb (yellow). The linker
to the SP domain of C2a shown in blue and that to Bb is shown in
green. The additional N terminus of C2a is shown in red. The
sugar molecule of C2a that is located at the domain interface
near the α7 helix is shown in white and labeled as NAG. The
magnesium ion of C2a is shown in silver and that of Bb is shown
in yellow.
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