Figure 3.
FIGURE 3. Structural basis of inhibition. The SU11652
inhibitor interacts with the ATP binding cleft through a network
of hydrogen-bonding interactions with main-chain atoms from the
kinase hinge region and van der Waals interactions with residues
from the N and C lobe together with Leu-162 from the T helix.
The structure of the inhibitor is shown in the inset. The
(diethylamino)ethyl moiety (highlighted) is disordered in the
crystal structure.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2007,
282,
6833-6842)
copyright 2007.
T helix.
The structure of the inhibitor is shown in the inset. The
(diethylamino)ethyl moiety (highlighted) is disordered in the
crystal structure.