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Figure 3.
Figure 3. Local Interactions between CaM Lobes and RYR1
Anchors Are Similar to the CaM/smMLCK Complex
Superposition
of the Cα atoms of (A) the C lobe of CaM (residues 84 to 146)
and (B) the N lobe of CaM (residues 5 to 75) from the RYR1 and
smMLCK complexes. Only the hydrophobic anchors of the peptides
(Trp3620 and Phe3636 in RYR1, Trp800 and Leu813 in smMLCK) and
the CaM residues that interact with them are shown. For the RYR1
complex, the peptide chain is drawn as a white ribbon, with the
anchors shown as thick sticks, while the CaM residues are shown
as sticks, with the carbon atoms colored in blue, nitrogen in
slate, oxygen in red, and sulfur in orange. The peptide chain
for smMLCK is shown in cyan, and residues from the CaM/smMLCK
complex are represented as thin sticks.
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