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Figure 3.
Figure 3: Details of the intermolecular contacts in the
H3(1–15)K4me3 peptide–BPTF PHD finger complex and comparison
with its H3(1–15)K4me2-bound counterpart. a, Intermolecular
backbone interactions between the A1–T6 segment of bound
H3(1–15)K4me3 peptide and the PHD finger in the complex. b,
Intermolecular hydrogen-bonding interactions involving the
guanidinium group of R2 in the complex. c, Superposition of free
(coloured green) and H3(1–15)K4me3-bound complex (coloured
yellow) of the BPTF PHD finger. d, e, Positioning of the
trimethylated lysine of the H3(1–15)K4me3 peptide (d) and the
dimethylated lysine of the H3(1–15)K4me2 peptide (e) within a
four-aromatic-amino-acid cage of the BPTF PHD finger. Two
bridging water molecules link the NH of K4me2 to the carboxylate
of D6, as indicated by dashed lines.
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