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Figure 3.
FIGURE 3. HSV POL replicating and inhibiting model. A,
replicating model. The carbon atoms of HSV POL shown in stick
are light gray, whereas those of primer DNA strand and dTTP are
dark gray and those of the template are purple. Black dashed
lines are shown for hydrogen bonds and ion interactions
involving the incoming nucleotide and catalytic ions. B, model
of Acyclovir·HSV POL dead-end complex. Hydrogen bonds
involving Acyclovir are shown in black dashes. Key residues
interacting with the Acyclovir-incorporated DNA, including the
conserved KKKY motif (938-941), are shown. C, chemical structure
of PNU-183792, a 4-oxo-DHQ type of herpes polymerase inhibitor.
D, a novel inhibition mechanism of a family of broad spectrum
inhibitor 4-oxo-DHQ. Residues interacting with inhibitor are
highlighted.
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