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Figure 3.
Structural depiction of the CDR2 mutant interactions in the
c49c50 --pMHC complex. (A) The CDR2[beta] loop mutations (GAGI
to SVGM). The 2BNR model is depicted in red; the c49c50 TCR is
colored by atom type, mostly green; the c49c50 MHC is mostly
red. Dotted lines indicate contacts between mutated side chains
and MHC residues. (B) The CDR2[alpha] loop mutations (QSS to
PFW): Q155 of the MHC is pushed deeper into the pocket by the
close approach of F51, while W52 forces a tighter packing of the
CDR1[alpha] Y30 against W5 of the peptide. The 2BNR MHC is red
and the c49c50 TCRa is mostly orange. The figures were prepared
using PyMOL (DeLano 2002).
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