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Figure 3.
FIGURE 3. a, superposition of the protein backbones for
apo-PMM/PGM (Apo) and its complexes with G16P. DP,
dephospho-PMM/PGM; P, phospho-PMM/PGM. Domains 1–4 are shown
in green, yellow, red, and blue, respectively. G16P as bound to
phosphoenzyme is shown in magenta and to dephosphoenzyme is
shown in cyan. b, a close-up view of G16P in the active site of
the two PMM/PGM-intermediate complexes showing their different
relative binding positions. The protein backbone is shown in
solid (dephosphoenzyme) and semitransparent (phosphoenzyme).
Shown are hydrogen bonds between G16P and dephospho-PMM/PGM (c)
and phospho-PMM/PGM (d). Protein residues that contact the
intermediate are shown as sticks; water molecules are shown as
blue spheres.
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