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Figure 3.
A, the terminal region of the oligonucleotide (aqua)
interacts with NS3h chain A (red) via a hydrogen bond between
Thr^269 (T269) and the phosphate backbone and ring stacking
between nucleotide dU[1] and Trp^501 (W501; green). B, at the
point where the oligonucleotide (aqua) enters the binding groove
of chain B (blue), interactions identical to those with chain A
are observed (Trp^501-dU ring stacking and Thr^269-phosphate
hydrogen bond formation).
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