Figure 3.
Proposed mechanisms of the Gfh1 action. A and B, the
flexibility and the number of the acidic residues at the CC tip
of Gfh1 allow for the alternative binding (MG1 or MG2) of the
Mg^2+ ions. C, two hypothetical pathways (competitive and
noncompetitive) by which the Gfh1 protein may inhibit nucleotide
addition. cMg1 and cMg2 are the two catalytic metals, whereas
iMg is a putative inhibitory Mg^2+ ion.
The above figure is reprinted
from an Open Access publication published by the ASBMB:
J Biol Chem
(2006,
281,
1309-1312)
copyright 2006.
