Figure 3.
Fig. 3. The ICAM-3/ [L] [2] binding interface.
(A) The interface residues are shown in light cyan and light
gold for ICAM-3 and the I domain, respectively. The metal ion,
oxygens, and nitrogens are shown as magenta, red, and blue
spheres, respectively. Water molecules are shown as red spheres.
Metal coordination is shown by black dashed lines. Hydrogen
bonds and a salt bridge between Lys-42 in ICAM-3 and Glu-241 in
the I domain are represented by silver dashed lines. Residues
involved in the hydrophobic patch are colored in silver. For
clarity, MIDAS residues are omitted. (B) Structural elements
that stabilize the conformation of the CD loop of ICAM-3. The CD
and EF loops are colored in yellow and green, respectively. Only
relevant side chains are shown in this figure for clarity.
Hydrophobic, neutral hydrophilic, and basic residues are colored
in orange, cyan, and blue, respectively. The broken lines
represent hydrogen bonds, whereas the silver ball is a bound
water molecule. A was prepared with RIBBONS (43), and B was
prepared with SETOR (44).
[L] 
[2] binding interface.
(A) The interface residues are shown in light cyan and light
gold for ICAM-3 and the I domain, respectively. The metal ion,
oxygens, and nitrogens are shown as magenta, red, and blue
spheres, respectively. Water molecules are shown as red spheres.
Metal coordination is shown by black dashed lines. Hydrogen
bonds and a salt bridge between Lys-42 in ICAM-3 and Glu-241 in
the I domain are represented by silver dashed lines. Residues
involved in the hydrophobic patch are colored in silver. For
clarity, MIDAS residues are omitted. (B) Structural elements
that stabilize the conformation of the CD loop of ICAM-3. The CD
and EF loops are colored in yellow and green, respectively. Only
relevant side chains are shown in this figure for clarity.
Hydrophobic, neutral hydrophilic, and basic residues are colored
in orange, cyan, and blue, respectively. The broken lines
represent hydrogen bonds, whereas the silver ball is a bound
water molecule. A was prepared with RIBBONS (43), and B was
prepared with SETOR (44).