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Figure 3.
Figure 3. Critical interactions in Pals1 internal PDZ binding.
(a) Par-6 PDZ -C-terminal ligand interactions. The
peptide-binding pocket from the C-terminal peptide -Par-6 PDZ
complex (PDB entry 1RZX) is shown. Peptide residues are labeled
by amino acid and PDZ domain residues are labeled by amino acid
and sequence number. The distance between the C terminus and
Lys165 is shown (solid line) along with interactions between the
carboxylate and the PDZ backbone (dashed lines). (b) Par-6 PDZ
-Pals1 internal ligand interactions. The interactions between
the PDZ domain and peptide are shown as in a.
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