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Figure 3.
Figure 3. Stereo view of the ligand binding site in the
structures of W168F mutant of PfTIM complexed with sulfate and
G2P. (a) Fit of the sulfate ion to the electron density in a
F[obs] -F[calc] omit map contoured at 2.5s. (b) Superposition of
the active sites of sulfate complexes of TrypTIM (green), C.
elegans TIM (indigo) and W168F mutant of PfTIM (colored by atom)
showing the differences in the protein-ligand interactions. (c)
G2P at the active site of the B-subunit of W168F-G2P complex is
shown with density from the F[obs] -F[calc] omit map contoured
at 2.5s. (d) Hydrogen bonding interactions (dotted lines) of G2P
with the polypeptide.
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