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Figure 3.
Figure 3: The binding sites for ligand-mimetic antagonists and
fibrinogen at the alpha- /
beta- subunit
interface. a, Mapping of fibrinogen binding sensitive
mutations20,49,50 in  [IIb]
 [3].
C atoms
of fibrinogen-binding sensitive residues are shown as spheres in
the same colour as the domains in which they are present. The
tirofiban-bound structure is shown. b -f, Binding of ligands or
pseudoligands to [IIb]
[3]
(b -e) and binding of (f) cyclo Arg-Gly-Asp-D-Phe-N-methyl-Val
(cyclo RGDfV) to [V]
[3]
(ref. 8). The orientation is identical to that in a. The and
subunits
are shown in magenta and cyan, respectively. Small molecules are
shown as ball-and-stick models with their carbon, nitrogen,
oxygen, sulphur and arsenic atoms coloured yellow, blue, red,
green and grey, respectively. Hydrogen bonds are shown as dotted
lines. Ca^2+ and Mg2+ ions are gold and silver spheres,
respectively. The ligand and S123 coordinations to the MIDAS
metal are shown as thin grey lines.
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