Figure 3.
Figure 3. Thrombin exosite interactions. (a,b) Thrombin
interacts closely with antithrombin by forming exosite
interactions in the -loop
(a) and the Na^+-binding region (b) (colored as in Fig. 2a). (c)
The heparin mimetic (SR123781) used in crystallization is
labeled from A on the nonreducing end to P on the reducing end.
It is composed of a thrombin-binding site (ABC) and an
antithrombin-binding site (LMNOP). The interactions with
thrombin and antithrombin are indicated by lines, with solid
lines indicating a salt bridge, dashed lines hydrogen bonds,
dashed-dotted lines for water-mediated hydrogen bonds, and
dotted lines for potential interactions (only for Lys240).
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2004,
11,
857-862)
copyright 2004.
-loop
(a) and the Na^+-binding region (b) (colored as in Fig. 2a). (c)
The heparin mimetic (SR123781) used in crystallization is
labeled from A on the nonreducing end to P on the reducing end.
It is composed of a thrombin-binding site (ABC) and an
antithrombin-binding site (LMNOP). The interactions with
thrombin and antithrombin are indicated by lines, with solid
lines indicating a salt bridge, dashed lines hydrogen bonds,
dashed-dotted lines for water-mediated hydrogen bonds, and
dotted lines for potential interactions (only for Lys240).