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Figure 3.
FIG. 3. Lovastatin and LFA878 inhibit the binding of mAb
R7.1 to LFA-1 in human blood in vitro. The binding of
fluorescein isothiocyanate-labeled mAb R7.1 to leukocytes in
human whole blood was quantified in the presence of lovastatin
(Lov.) (100 µM) (A) or LFA878 (30 µM) (B) by flow
cytometry as described under "Experimental Procedures." Red
profiles indicate the binding of mAb R7.1 to lymphocytes,
granulocytes, or monocytes in the presence of compound; black
profiles such binding in the presence of the solvent control. A
representative experiment is shown.
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