|
Figure 3.
Fig. 3. Structural comparison of Htra proteins. (a)
Structural alignment of the protease backbone atoms. N- and
C-termini (NT, CT), loop5 (L5) and resdiues of the catalytic
triade are assigned in ball and stick for clarity. The following
colour code was used: DegS is magenta, DegP is cyan and
HtrA2/Omi is coloured in blue. (b) Structural alignment of the
PDZ domain with the same colour code used in (a). Selected
secondary structure elements are marked. (c) Overlay of the
active site residues from DegS, DegP, HtrA2/Omi and trypsin
(in green). Residue numbers are assigned with respect to the
DegS sequence. (d) Crystal structure of DegP with the protease
domain superimposed onto DegS and the domain colour code
according to the DegS structure in Fig. 1(a). (e) Crystal
structure of HtrA2/Omi with the protease domain structurally
aligned to DegS and the same colour code as for figure (d).
|
