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Figure 3.
Figure 3. Conformation of the MIDAS Motif and the bF-a7
Turn(A) Superposition of the MIDAS motifs of factor B and a2
integrin A domains. The structures are superposed on their
central b sheets. Color-coding is as follows: factor B Ca,
green; side chains, black; ligand mimetic, gold and red; a2 A
domain Ca and side chains, white (semitransparent). The metal
ion ("M") is in purple, with coordinating oxygens from S253,
S255, T328, and two water molecules ("W") in red. The side
chains of D251 and D364 form water-mediated bonds to the metal
ion.(B) Overlay of the bF-a7 turns of factor B (red) with the
open (translucent green) and closed (yellow) conformations of
the integrin aM I domain. The Ca positions of analogous residues
(M433 in factor B; F302 in aM) are indicated.
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