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Figure 3.
Fig. 3. Model of the complex between CD55 and the von
Willebrand factor type A domain (vWF-A) of factor B. b and d
show two views of the complex between CD55 and the vWF-A domain
of factor B generated as described in the text. CD55 is oriented
as in Fig. 1a Left. b shows a surface representation, and d
shows a secondary structure trace for both molecules, which are
colored as follows: CD55, the hydrophobic potential was
calculated by using the program GRID and mapped onto the surface
in AESOP (43) colored from green (most favorable for hydrophobic
probe interaction) via yellow to white; and vWF-A of factor B,
residues implicated in CD55 binding are colored red, and those
implicated in C3b binding are colored orange; positions where
mutation has no effect on CD55 sensitivity are colored blue. a
and c show each molecule rotated 90° away from the view
shown in b to allow inspection of the surfaces buried in the
interface. CD55 is shown in the same view as in that of Fig. 1a
Right.
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