Figure 3.
Figure 3. Models for the complex of IL-18 and IL-18R ,
and interactions among IL-18, IL-18R and
IL-18R .
(a) Crystal structure of the complex of IL-1 and
IL-1RI (PDB entry 1ITB). IL-1 residues
in sites A and B are red and orange, respectively. (b) Modeled
structure of the complex of IL-18 and IL-18R .
IL-18 residues in sites I, II and III are red, orange and blue,
respectively. In a and b, the molecule on the right is viewed as
rotated by 90° about the vertical axis relative to the image on
the left. (c) Dose-response curves of surface plasmon resonance
for wild-type IL-18 to immobilized IL-18R or
to immobilized IL-18R .
Concentration of wild-type IL-18 is also indicated. (d) Response
curves of surface plasmon resonance for IL-18R for
to the complex of immobilized IL-18R with
wild-type IL-18 or the site III mutant proteins.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2003,
10,
966-971)
copyright 2003.
,
and interactions among IL-18, IL-18R 
.
(a) Crystal structure of the complex of IL-1 
and
IL-1RI (PDB entry 1ITB). IL-1 
.
IL-18 residues in sites I, II and III are red, orange and blue,
respectively. In a and b, the molecule on the right is viewed as
rotated by 90° about the vertical axis relative to the image on
the left. (c) Dose-response curves of surface plasmon resonance
for wild-type IL-18 to immobilized IL-18R