Figure 3.
Figure 3: Comparison of PDE5 and PDE4 active sites. a,
Superimposed C traces
of PDE5 (red) and PDE4 (blue)9 showing the difference between
the two folds at the active site. Residues 304 -325 of PDE5 and
660 -680 of PDE4D are shown with deeper colours to emphasize the
differences in this region. The stick model of sildenafil is
shown in yellow and that of zardaverine^9 in green. b, Surface
representation of active site pocket of PDE5. The molecular
surface is coloured according to electrostatic potential
(negative and positive in red and blue, respectively). Residues
that form the active site pocket are shown in green. The bound
sildenafil in PDE5 is shown as a stick model.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2003,
425,
98-0)
copyright 2003.
traces
of PDE5 (red) and PDE4 (blue)9 showing the difference between
the two folds at the active site. Residues 304 -325 of PDE5 and
660 -680 of PDE4D are shown with deeper colours to emphasize the
differences in this region. The stick model of sildenafil is
shown in yellow and that of zardaverine^9 in green. b, Surface
representation of active site pocket of PDE5. The molecular
surface is coloured according to electrostatic potential
(negative and positive in red and blue, respectively). Residues
that form the active site pocket are shown in green. The bound
sildenafil in PDE5 is shown as a stick model.