|
Figure 3.
FIG. 3. Binding site of the APP peptide. Stereoview of the
APP peptide binding to the Dab2-DH (A) and the Dab1-DH (B).
Solid lines indicate hydrogen bonds. Carbons are shown in gray
in Dab-DH and in green in the APP peptide (selected residues are
numbered). Note that the side chain conformation of tyrosine of
the APP peptide at the (-5) position differs between the Dab2-DH
and Dab1-DH. Boxed residues were mutated for the experiment
shown in Fig. 4.
|
