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Figure 3.
Fig. 3. Pocket-tip interaction. (A) Ribbon model of the
Rpb7 tip binding with its two outermost loops (15) to the five
protein regions (7) that line the pocket. The view is from the
"back," roughly the reverse of that shown in Figs. 1 and 2A.
Colors are as described for Fig. 2 except that switch region 5
is green. (B) Sequence alignments of protein regions are as
described for A. Hs, Homo sapiens; Dm, Drosophila melanogaster;
Sp, Schizosaccharomyces pombe; Sc, S. cerevisiae; Mj,
Methanococcus jannaschii; Ss, Sulfolobus solfataricus. Conserved
residues are highlighted. The stars below the alignments
indicate invariant residues. The figure was prepared with
RIBBONS (54).
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