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Figure 3.
Figure 3. Shape complementarity of benzoic acid (a) and
hapten (b) in the antibody 4C6 combining site. The Fab
4C6-binding pockets are shown with the molecular surfaces (1.4
Å probe radius). The shape of active sites differs
dramatically between two structures primarily due to the
side-chain of TrpL89, which flips downward to form the base of
the hapten-binding pocket by the rotation of the x[2] angle
about 65° on hapten binding. For further information, see
the text and Figure 4. The Figure was generated in GRASP. [59.]
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