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Figure 3.
FIG. 3. Conformation of the proximal juxtamembrane region
in IRK. Stereo views of the proximal juxtamembrane region and
the N-terminal kinase lobe from the IRKD1132N structure (A) and
the tris-phosphorylated IRKY984F structure (13) (B) are shown.
The view is from above with respect to the view in Fig. 3. The
juxtamembrane region is shown in ball-and-stick representation
with carbon atoms colored orange, nitrogen atoms colored blue,
and oxygen atoms colored red. The side chains of selected
residues of the N-terminal kinase lobe are shown in ball-
and-stick representation with carbon atoms colored gray,
nitrogen atoms colored blue, and oxygen atoms colored red.
Semi-transparent van der Waals' surfaces in A indicate
hydrophobic packing of Tyr-984 with Leu-1045 and Val-1065. C,
schematic diagram (approximate spatial layout) showing the
invariant residues in the insulin receptor subfamily that form
the Tyr-984 binding pocket. The residue labels are placed
alongside the C  atoms of the side
chains. The backbone nitrogen atoms of Trp-989 and Ser-1067 are
included as well as the carbonyl oxygen of nonconserved Val-985
(dark gray). Hydrogen bonds are depicted by dashed lines, and
van der Waals' interactions (<3.8 Å) with Tyr-984 are
depicted as concentric half-circles.
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